Jake Cronenworth struck out looking with the bases loaded to end the sixth inning.

He wasn’t going to come up empty again.

The Padres’ second baseman avenged an early missed opportunity with a single in the same situation in the 10th inning, sending the Padres to a walk-off, 3-2 victory over the Texas Rangers to start the final homestand before the All-Star break.

The Padres are hopeful that this win wasn’t preceded by a significant loss.

Moments before Cronenworth’s walk-off in front of a sellout crowd of 45,114, Xander Bogaerts grabbed at his right hamstring after whiffing at a first-pitch changeup. Bogaerts was tended to for several moments by a trainer before exiting the game for the second time in five days with cramping.

“Pretty nasty cramp,” Padres manager Mike Shildt said. “Knotted up on him. Tried to get it to relax. Doesn’t sound like it’s hamstring (muscle) related, but it’s happening a little more frequently so we’ve got to do the proverbial deep dive to figure out what that looks like.”

It was quad cramping that forced Bogaerts from the ninth inning on June 29 in Cincinnati. He did not miss any additional time and was hopeful that will be the case this time, too.

Friday’s issue struck without any warning.

“That’s why it was a little weird,” Bogaerts said. “I haven’t felt one thing before the whole day and after the swing … I could barely walk. (But) … I’m good now.”

Bryce Johnson finished Bogaerts’ 10th-inning at-bat and struck out on two pitches, bringing Cronenworth to the plate with two outs and the bases loaded.

Against a left-hander, too.

Just like in the sixth inning after Luis Arraez’s game-tying single.

At that point, Padres manager Mike Shildt still had the right-handed-hitting Jose Iglesias in his holster — someone he’s used in similar spots on occasion — and elected to stick with Cronenworth against left-hander Hoby Milner.

In the 10th, Iglesias had already flied out as a pinch-hitter for Martin Maldonado in the ninth, so the only option was to stick with Cronenworth.

The two-time All-Star delivered this time, pulling a 2-1 slider from left-hander Robert Garcia to right field for his fifth walk-off at Petco Park.

Only Will Venable, with six, has more in the history of the Padres’ Gaslamp park.

“It’s not too often you get an opportunity again with the bases loaded to win the game,” Cronenworth said.

He added: “I think I get the best out of myself in those bigger spots. I think it’s something I thrive in, in those positions. I just want to help the team win.”

The walk-off ensured the Padres got something from a stellar day on the mound from the staff.

Randy Vásquez allowed just Marcus Semien’s two-run double in the second inning over six quality innings. Jeremiah Estrada, Jason Adam and Robert Suarez each escaped scoreless innings and Adrián Morejón stranded the automatic runner and a walk in the 10th inning to give a struggling offense one more shot at a win.

An intentional walk to Manny Machado — sitting just three hits shy of 2,000 after homering in a two-hit day — started the rally and Gavin Sheets’ soft, one-out single to center loaded the bases.

Before that, the Padres spent much of Friday afternoon trying to erase Semien’s two-run double.

Machado’s 440-foot homer to center in the third inning got the Padres halfway there. Then in the sixth, Fernando Tatis Jr. tripled off right fielder Adolis Garcia’s glove to open the inning and ultimately scored on Luis Arraez’s single through the left side of the infield to tie the game.

The pitching staff might have had a little more room to breathe if Trenton Brooks wasn’t erased at second base in the fifth inning on a technicality.

The 30-year-old journeyman roped a 102 mph ball off the right-field wall with one out and slid into second base ahead of shortstop Corey Seager’s tag. Seager, however, kept his glove on Brooks as he popped up from his slide and was rewarded with an out after a delayed replay review showed that the Padres designated hitter lost contact with the bag for just a moment.

In fact, that was likely Shildt’s contention as he discussed the overturned call with crew chief Alan Porter after the call to New York removed Brooks from second base.

A manager must hold a hand up immediately after a play to signal a potential challenge, the start of a 15-second window to make a decision.

After Brooks’ “double” — which was later scored a single — Rangers manager Bruce Bochy and his bench appeared to struggle to get the attention of plate umpire Alex MacKay.

That prompted a discussion with Shildt before the play was sent to New York and after the safe call on the field was overturned.

Managers are usually automatically ejected immediately upon arguing a decision from New York.

“I think they did the right thing by allowing me to have the conversation so I didn’t get ejected,” Shildt said. “ … They have hard jobs, man. I’m not going to be that guy that just piles on them when I have an opportunity. Fact of the matter is (Bochy) was looking to make a challenge, he was doing it right and they were able to challenge it.”