Now that the San Francisco 49ers’ first preseason game is in the books, the roster outlook is starting to get a bit clearer. What would a potential 53-man roster look like after the preseason loss to the Denver Broncos? Quarterback (2): Brock Purdy, Mac Jones Jun 11, 2025; Santa Clara, CA, USA; San Francisco 49ers quarterbacks Mac Jones (10) and Brock Purdy (13) work on passing drills during a team OTA at Levi’s Stadium. Mandatory Credit: D. Ross Cameron-Imagn Images / D. Ross Cameron-Imagn Images Carter Bradley may not even stick on the practice squad after his performance, and the 49ers cut Tanner Mordecai for Bradley. Kuris Rourke will be on the IR to start the year. Running Back (5): Christian