The NFL regular season is scheduled to start soon. In its comprehensive 18-week layout, Week 1 will begin on September 4 and culminate on September 8. Quarterback Patrick Mahomes #15 of the Kansas City Chiefs in action during the first quarter vs Chicago Bears(Getty Images via AFP) Here is the full day-by-day schedule of 2025’s Week 1: Thursday (September 4) Dallas Cowboys at Philadelphia Eagles 8:20 PM ET Stream on NBC, Peacock, TV provider Friday (September 5) Kansas City Chiefs at Los Angeles Chargers 8 PM ET Stream on YouTube Sunday (September 7) Tampa Bay Buccaneers at Atlanta Falcons 1 PM ET Stream on FOX, YouTube Cincinnati Bengals at Cleveland Browns 1 PM ET Stream on FOX, YouTube Miami