Week 1 of the 2025 NFL season features an in-state, AFC North matchup between the Cincinnati Bengals and Cleveland Browns. The Browns are 5.5-point spread home dogs versus the high-octane, pass-heavy Cincinnati Bengals. Keep reading below to find our best Bengals vs. Browns player prop and game picks and why we are backing each of them. A strong surge in the second half of last season, including five straight wins to close out the year, has Bengals fans excited for the potential of this campaign.