The Los Angeles Chargers made major changes to their running back room entering 2025. Los Angeles let its leading rusher, J.K. Dobbins, walk in free agency—he eventually signed with the Denver Broncos—and drafted Omarion Hampton with the 22nd overall pick in the 2025 NFL Draft. Los Angeles also added veteran Najee Harris, who has surpassed 1,000 rushing yards in each of his four NFL seasons with the Pittsburgh Steelers. Harris was expected to be the team’s lead running back, but an eye injury suffered on July 4 has cast doubt on his availability for the season opener.