Running backs Isaac Brown and Keyjuan Brown as well as linebacker/safety Antonio Watts are out for Louisville football’s Week 13 ACC game against SMU, according to the Thursday night injury report.

Quarterback Miller Moss is listed as questionable while linebacker T.J. Quinn and tight end Jacob Stewart are probable.

Isaac Brown has been struggling with injuries all season but missed the last two games after suffering what appeared to be a hamstring injury at Virginia Tech. He had three straight 100-yard games up to that point, including a career-high 205 rushing yards in the Cards’ 38-24 win against Boston College.

Keyjuan Brown had been the Cardinals’ starter in Isaac Brown’s absence and had back-to-back 100-yard rushing performances. Duke Watson will likely be Louisville’s starting running back.

Louisville and SMU are set to kick off at noon Saturday at Gerald Ford Stadium in Dallas.

Reach Louisville football, women’s basketball and baseball beat writer Alexis Cubit at acubit@gannett.com and follow her on X at @Alexis_Cubit.

This article originally appeared on Louisville Courier Journal: Louisville vs SMU football injury news for Week 13 ACC game